Named after JC Howe who invented the formula over sixty years ago, this all natural supplement helps stop muscle cramping without side effects. Trainers say one tube can end tie up for 30 days. Treat in the morning before vigorous activity. Contains a proprietary blend of vitamins that produce energy more efficiently. Each dose contains min 65 mg thiamine, 670 mg niacinamide, 43 mg vitamin B6, 34 mg d-pantothenic acid, 26 mg riboflavin and 0.04 mg vitamin B12.